New PDF release: Advances in Eicosanoid Research

By J. R. Vane (auth.), C. N. Serhan, H. D. Perez (eds.)

ISBN-10: 3662040476

ISBN-13: 9783662040478

ISBN-10: 3662040492

ISBN-13: 9783662040492

Over the previous few years, we now have witnessed large development within the box of eicosanoids and their healing functions. Receptor an­ tagonists for leukotrienes were proven as anti-inflammatories and are out there as a therapy for bronchial asthma. Receptor agonists for professional­ stacyclin are being proven for the therapy of peripheral vascular dis­ ease, and selective inhibitors of cyclooxygenase variety II have been simply ap­ proved for the remedy of rheumatoid arthritis. a lot of these advancements are the end result of decades and man-hours of cautious examine. the sector has now entered an upswing that might bring about novel thera­ peutic functions in the subsequent 10 years. New molecules and me­ diators were pointed out, new enzymes and pathways elucidated and new healing techniques have emerged. the concept that of ei­ cosanoids as "pro-inflammatory" molecules is being challenged, and their position as regulators is more and more well-known. actually, a few of these molecules might be very important endogenous anti inflammatory agents.

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Pastoris is biologically active . 1 Similarity of the Group-IIA and the Group-V PLA2S The classification of group-V PLA 2 was based on sequence alignments with other sPLA 2s . These comparisons revealed that the group-V enzyme contains 12 cysteines but lacks the Cys-ll to Cys-77 disulfide bond found in the group-I enzymes. The group-V enzyme also lacks the C-terminal extension found in the group-II enzymes. For these reasons, the group-V enzyme was placed in its own group. In the past, it has been Human Group-V Phospholipase-A, Expression in Pichia pastoris 47 recognized that all sPLA 2s are characterized by their low molecular weight, millimolar calcium requirement and high percentage of disulfide bonds.

Yijun Chen . As shown in Fig. 7, the Western blot reveals that approximately 90% of the His tag has been removed . It is unlikely that the His tag interferes with antibody recognition, because the proteins were separated under denaturing conditions. Thus, the final preparation of the group- V PLA2 is predominantly recombinant enzyme with the correct N-terminus . 5 Activity Measurements The specific activity of the human group-V PLA 2 was found to be 270 nmol/min/mg using mixed micelles containing TX-IOO and DPPC.

Inflammopharmacology 3:335-345 Gustafson-Svard C, Lilja I, Hallbook 0 , Sjodahl R (1996) Cyclooxygenase-I and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats. Gut 38:79-84 Hamberg M, Svensson J, Samuelsson B (1975) Thromboxanes : a new group of biologically active compounds derived from prostaglandin endoperox ides. Proc Natl Acad Sci USA 72:2994-2998 Harris RC (1996) The macula densa: recent developments . J Hypertens 14:815-822 Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, Breyer MD (1994) Cyclooxygen ase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

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Advances in Eicosanoid Research by J. R. Vane (auth.), C. N. Serhan, H. D. Perez (eds.)


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