By Saverio Cinti MD (auth.), Giamila Fantuzzi PhD, Theodore Mazzone MD (eds.)
This booklet provides a entire survey of adipose tissue, its physiological services, and its function in sickness. the quantity spans the full variety of adipose tissue reviews, from easy anatomical and physiological study to epidemiology and medical reviews. The authors are distinct researchers, clinicians and epidemiologists. they've got integrated groundbreaking fresh reports into conventional versions of adipose tissue homes.
Chapters on famous houses of adipokines leptin and adiponectin are complemented by means of an advent to a singular view of adipose tissue as a dynamic organ that regulates systemic substrate availability and metabolism, in addition to a number of different discrete features. This novel thought is elevated.
Worldwide traits in weight problems are mentioned from an evolutionary viewpoint and explanations of the present weight problems epidemic are postulated. also, researchers and clinicians learn the organization and strength position of adipose tissue in illness mediation and provide epidemiological proof. This quantity concludes with a considerate and cutting edge dialogue of varied methods to inducing and maintaining weightloss in overweight
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This ebook provides a complete survey of adipose tissue, its physiological capabilities, and its function in affliction. the amount spans the whole variety of adipose tissue reports, from easy anatomical and physiological learn to epidemiology and scientific experiences. The authors are unique researchers, clinicians and epidemiologists.
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Extra resources for Adipose Tissue and Adipokines in Health and Disease
This is accompanied by activation of the leptin gene; these cells are also immunoreactive for leptin (24,25). 5. Hypoplasia (Negative Energy Balance: Caloric Restriction, Fasting) The morphology of the adipose organ during fasting is quite characteristic, because a variable amount of slimmed cells are present in WAT. , it has a specific ultrastructural morphology: cytoplasmatic irregular and thin projections with numerous invaginations rich in pinocytotic vesicles. These projections enlarge in proximity of the nucleus and of the residual lipid droplet.
Last, WAT, through the secretion of various hormones such as leptin or adiponectin and the way it stores or release lipids, controls in part the amount of lipids stored in other tissues and the sensitivity to insulin of tissues such as muscles or liver. Therefore, modifications of WAT metabolism may be implicated in the excessive accumulation of lipid substrates in other tissues, their unfavorable consequences (lipotoxicity ), and the development of insulin resistance and diabetes. 2. TAG SYNTHESIS AND STORAGE TAG stored in adipocytes are synthesized within these cells from fatty acids and glycerol-3-phosphate (G3P).
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Adipose Tissue and Adipokines in Health and Disease by Saverio Cinti MD (auth.), Giamila Fantuzzi PhD, Theodore Mazzone MD (eds.)